Symbol Name ID |
Nod2
nucleotide-binding oligomerization domain containing 2 MGI:2429397 |
Darker colors indicate more annotations |
Human Phenotypes | Neutrophilia |
Leukocytosis |
Leukopenia |
Hemophagocytosis |
Stomatitis |
Pericarditis |
Lymphadenopathy |
Abnormality of the spleen |
Splenomegaly |
Hepatosplenomegaly |
Gastrointestinal inflammation |
Crohn's disease |
Recurrent gastroenteritis |
Peritonitis |
Acute hepatitis |
Chronic hepatitis |
Pancreatitis |
Uveitis |
Iridocyclitis |
Nongranulomatous uveitis |
Inflammatory abnormality of the eye |
Epididymitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Fasciitis |
Inflammatory abnormality of the skin |
Eczematoid dermatitis |
Erysipelas |
Erythema nodosum |
Skin rash |
Discoid lupus rash |
Maculopapular exanthema |
Malar rash |
Myositis |
Pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Autoimmunity |
Autoimmune antibody positivity |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Asthma |
Recurrent infections |
Meningitis |
Disease(s) Associated with NOD2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
asthma | |||||||||||||||||||||||||||||||||||||||||||||||||||||
autoimmune disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Behcet's disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||
Blau syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||||
familial mediterranean fever | |||||||||||||||||||||||||||||||||||||||||||||||||||||
graft-versus-host disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||
leprosy | |||||||||||||||||||||||||||||||||||||||||||||||||||||
systemic lupus erythematosus |
Mouse Phenotypes | impaired macrophage phagocytosis |
impaired neutrophil phagocytosis |
increased susceptibility to induced colitis |
increased double-negative T cell number |
increased neutrophil cell number |
increased CD4-positive, alpha-beta T cell number |
increased leukocyte cell number |
abnormal macrophage morphology |
decreased IgG level |
abnormal T-helper 1 physiology |
abnormal macrophage physiology |
increased circulating interferon-gamma level |
increased circulating interleukin-2 level |
increased circulating tumor necrosis factor level |
abnormal cytokine level |
abnormal interferon level |
abnormal interleukin level |
abnormal tumor necrosis factor level |
abnormal immune system morphology |
abnormal Peyer's patch morphology |
increased Peyer's patch number |
enlarged Peyer's patches |
abnormal lymph node morphology |
abnormal lymph node B cell domain morphology |
enlarged lymph nodes |
abnormal immune system physiology |
abnormal cytokine secretion |
increased interleukin-1 beta secretion |
decreased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
decreased susceptibility to induced arthritis |
decreased susceptibility to endotoxin shock |
abnormal response to infection |
abnormal susceptibility to infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||
Nod2em1(IMPC)Mbp/Nod2em1(IMPC)Mbp | ||||||||||||||||||||||||||||||||||||
Nod2tm1Daph/Nod2tm1Daph | ||||||||||||||||||||||||||||||||||||
Nod2tm1Flv/Nod2tm1Flv | ||||||||||||||||||||||||||||||||||||
Nod2tm1Jhgt/Nod2tm1Jhgt | ||||||||||||||||||||||||||||||||||||
Nod2tm1Mka/Nod2tm1Mka | ||||||||||||||||||||||||||||||||||||
Nod2tm1Pmu/Nod2tm1Pmu | ||||||||||||||||||||||||||||||||||||
Nod2tm1Vmd/Nod2tm1Vmd |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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